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Sources and Issues Next Release

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Last edited: 2011-06-14

Applies to iRefIndex release: xxx

Release date: xxx

Authors: Ian Donaldson, Sabry Razick and Paul Boddie

Database: iRefIndex (

Organization: Biotechnology Centre of Oslo, University of Oslo (

Description: This file lists interaction and protein sequence related resources used for the current build of the iRefIndex. Statistics for the iRefIndex are available and include a breakdown of interactors and interactions from each data source.



Hard Release date: July 1st.

Yeast taxon id changes See

New databases To Be Discussed

BioGrid interaction record ids (pre-build issue) To Be Done

Capture Biogrid interaction record ids so iRefWeb can link out to BioGrid.

  • The only interaction id available from the BioGrid files are already being used and also there in the iRefWeb

e.g <primaryRef db="grid" id="103" refType="identity" refTypeAc="MI:0356" dbAc="MI:0463" />

RIGID recalculation (pre-build issue)

See bug 242. Modify existing RIGID table or loose continuity of iRIGIDs with last release.

Taxon specific MITAB files (post-processing issue)

Taxon specific files should contain interactions ONLY if one or both taxa, taxb have the appropriate taxon (regardless of what the source database said the interaction taxon was. Change README. Example see PMID A "mouse" interaction from HPRD lists only human interactors (the paper is about mouse and they have made a transfer to human without noting what they have done.) As a result, this human interaction ends up in the mouse MITAB (because HPRD says it was mouse). BioGRID correctly curates the paper as about mouse.

CORUM methods (code change implemented)

Ensure that all CORUM methods (with MI terms) are parsed.

  • This is now fixed (Sabry) - please get the latest mapper from CVS

Repeated lines (post-processing issue)

There are multiple lines that are repeated many times. These appear to arise from BIND 3DBP division (see for example lines 5,13,117,125 in Ecoli MITAB and others arising from BIND ID 92720 - 44 pieces of experimental evidence and 5 PMIDs) because the accessions for the different experimental forms are not present in MITAB. See Antonio and bug# 245. Could be handled as a post-processing step on MITAB to take the unique set of all MITAB lines.

MITAB/irefscape canonicalization (post-processing issue)

Change this to choose canonical sequence rather than longest sequence (mapping score L). Examples GeneID 84148 and 512564 unnecessarily separates Grid interaction data from interaction data from other databases.

Decided not to chnage L method...instead:

Resolve by distributing non-canonicalized data as before AND a canonicalized MITAB file with complete provenance info (this will become the main MITAB file we release and it will support PSICQUIC services and we will drop non-canonicalised version in future releases). Also, canonicalize irefscape data and include provenace data for interactors in edge attribute viewer.

Requires review of current MITAB file format by Ian.

Other issues

  • Discuss the way to include I2D -- No I2D will not be included
  • Parse all new datasets to a temporary database and test before homogenizing. -- not required, no new data sources
  • Whether to use both BIND text and BIND_Translation OR only one of them
  • The default output data will be the canonical form. The MITAB will have the canonical Accession as the UIDA and UIDB. There will be new columns beforeCanonicalizationReferenceA, beforeCanonicalizationReferenceB. The aliases and the alternative identifiers will be of the canonical group not of a specific protein. With the new columns and all the references, it has to be tested whether the row width will exceed any thresholds (e.g. MySQL maximum row with), (I assume this would not be a problem).
  • For iRefScape, once the canonicalization is performed there will be no "uncanonicalize option" (currently there is a option to use canonical expansion).


This link in the Sources_and_Issues_Next_Release to download data seems to be downloading all data.If you go to the link available from their publication Link it points to 745 interactions, these are probably the one curated by MPIDB.

The tab file from MPIDB is NOT STANDARD MITAB, a custom parser will be required.


Innatedb has data from other sources as well. I see in the download page that these is a link for curated innateDB data and we should find out whether this is a collection of all data or are these curated by innatedb. Paul has made a parser for the PSI XML and this data will be from 2011-03-06. They say however that they update the MI TAB version every week.


They have non-proteins and protein fragments not only proteins as interactors. This database must be tested before homogenizing.

Interaction related resources

Source Format Location Version (date)
BIND Tab-delimited text file. (no longer available - see below).







These file are no longer available via ftp but are available from the authors. BIND archival content is now managed by Thomson Scientific. See and

For historical purposes, a snapshot of the the Blueprint web-site may be viewed at...

...via the internet archive at...*/

BINDTranslate PSI-MI 2.5 Version 1.0 (2010-12-15)
BioGRID PSI-MI 2.5 Version 3.1.77 (2011-06-01)

Note: date on last IMEx release file is from 2008

Release 9 (2010-04-13)
IntAct PSI-MI 2.5 2011-05-25
MINT PSI-MI 2.5 2010-12-21
MPACT PSI-MI 2.5 2008-01-10
MPPI PSI-MI 1.0 2004-06-01 (from archive)
OPHID PSI-MI 1.0 (This service no longer available, please refer to 2006-07-07
New for this release
InnateDB PSI-MI 2.5
Curated InnateDB Data
MPIDB MITAB format file (information) (general downloads) (specific download for MPI-LIT) (specific download for MPI-IMEX)

Downloaded on 2011-06-14
MatrixDB PSI-MI 2.5
2010-08-26 (timestamp)

Sequence related resources (not updated yet)

Source Format Location Version (date)
SEGUID Tab-delimited text
xxxx (timestamp)
UniProt Text
UniProtKB/Swiss-Prot (uniprot_sprot.dat.gz)
UniProt Knowledgebase Release xxxx (Downloaded xxxx ):
UniProt Text
UniProtKB/TrEMBL (uniprot_trembl.dat.gz)
UniProt, IsoForms FASTA uniprot_sprot_varsplic.fasta.gz
UniProt, SGD Tab-delimited text file.
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
UniProt, FLY Tab-delimited text file.
Drosophila: entries, gene names and cross-references to FlyBase.
NCBI, RefSeq GenPept
see *.protein.gpff.gz files
Release xxxx (Downloaded on xxxx )
NCBI, MMDB/PDB Tab-delimited text (Downloaded on xxxx )
NCBI, PDB sequences FASTA (Downloaded on xxxx )
NCBI Gene2Refseq Tab-delimited text
(Downloaded on xxxx )

All iRefIndex Pages

Follow this link for a listing of all iRefIndex related pages (archived and current).